Compile Data Set for Download or QSAR

Found 102 hits of affinity data for UniProtKB/TrEMBL: Q8IV61   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50244449 ((E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)...) Show SMILES CCCC(CCC)C(=O)OCC1(CO)C\C(=C/c2cn(C)c3ccccc23)C(=O)O1 Show InChI InChI=1S/C24H31NO5/c1-4-8-17(9-5-2)22(27)29-16-24(15-26)13-18(23(28)30-24)12-19-14-25(3)21-11-7-6-10-20(19)21/h6-7,10-12,14,17,26H,4-5,8-9,13,15-16H2,1-3H3/b18-12+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute at Frederick Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from RasGRP3 (unknown origin) expressed in cells				J Med Chem 51: 5371-86 (2008) Article DOI: 10.1021/jm800380b BindingDB Entry DOI: 10.7270/Q21V5DSQ
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50244450 ((E)-(2-(hydroxymethyl)-5-oxo-4-(pyridin-2-ylmethyl...) Show SMILES CC(C)CC(CC(C)C)C(=O)OCC1(CO)C\C(=C/c2ccccn2)C(=O)O1 Show InChI InChI=1S/C22H31NO5/c1-15(2)9-17(10-16(3)4)20(25)27-14-22(13-24)12-18(21(26)28-22)11-19-7-5-6-8-23-19/h5-8,11,15-17,24H,9-10,12-14H2,1-4H3/b18-11+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute at Frederick Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from RasGRP3 (unknown origin) expressed in cells				J Med Chem 51: 5371-86 (2008) Article DOI: 10.1021/jm800380b BindingDB Entry DOI: 10.7270/Q21V5DSQ
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50244449 ((E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)...) Show SMILES CCCC(CCC)C(=O)OCC1(CO)C\C(=C/c2cn(C)c3ccccc23)C(=O)O1 Show InChI InChI=1S/C24H31NO5/c1-4-8-17(9-5-2)22(27)29-16-24(15-26)13-18(23(28)30-24)12-19-14-25(3)21-11-7-6-10-20(19)21/h6-7,10-12,14,17,26H,4-5,8-9,13,15-16H2,1-3H3/b18-12+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.330	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Industrial Technology Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from recombinant human GFP-tagged RasGRP3 expressed in Escherichia coli BL21 after 5 mins by scintillation counting analysis...				Bioorg Med Chem 22: 3123-40 (2014) Article DOI: 10.1016/j.bmc.2014.04.024 BindingDB Entry DOI: 10.7270/Q2P270QK
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50017890 (CHEMBL3289012) Show SMILES CCCC(CCC)C(=O)OCC1(CO)C\C(=C/c2ccc3n(C)ccc3c2)C(=O)O1 Show InChI InChI=1S/C24H31NO5/c1-4-6-18(7-5-2)22(27)29-16-24(15-26)14-20(23(28)30-24)13-17-8-9-21-19(12-17)10-11-25(21)3/h8-13,18,26H,4-7,14-16H2,1-3H3/b20-13+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.340	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Industrial Technology Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from recombinant human GFP-tagged RasGRP3 expressed in Escherichia coli BL21 after 5 mins by scintillation counting analysis...				Bioorg Med Chem 22: 3123-40 (2014) Article DOI: 10.1016/j.bmc.2014.04.024 BindingDB Entry DOI: 10.7270/Q2P270QK
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50245022 ((E)-(2-(hydroxymethyl)-5-oxo-4-(quinolin-3-ylmethy...) Show SMILES CCCC(CCC)C(=O)OCC1(CO)C\C(=C/c2cnc3ccccc3c2)C(=O)O1 Show InChI InChI=1S/C24H29NO5/c1-3-7-18(8-4-2)22(27)29-16-24(15-26)13-20(23(28)30-24)12-17-11-19-9-5-6-10-21(19)25-14-17/h5-6,9-12,14,18,26H,3-4,7-8,13,15-16H2,1-2H3/b20-12+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.520	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute at Frederick Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from RasGRP3 (unknown origin) expressed in cells				J Med Chem 51: 5371-86 (2008) Article DOI: 10.1021/jm800380b BindingDB Entry DOI: 10.7270/Q21V5DSQ
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50280750 (CHEMBL4160361) Show SMILES CC(C)(C)C(=O)OCC1(CO)C\C(=C/c2ccc(Cl)cc2)C(=O)O1 Show InChI InChI=1S/C18H21ClO5/c1-17(2,3)16(22)23-11-18(10-20)9-13(15(21)24-18)8-12-4-6-14(19)7-5-12/h4-8,20H,9-11H2,1-3H3/b13-8+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	0.530	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50244451 ((E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)...) Show SMILES CC(C)CC(CC(C)C)C(=O)OCC1(CO)C\C(=C/c2cn(C)c3ccccc23)C(=O)O1 Show InChI InChI=1S/C26H35NO5/c1-17(2)10-19(11-18(3)4)24(29)31-16-26(15-28)13-20(25(30)32-26)12-21-14-27(5)23-9-7-6-8-22(21)23/h6-9,12,14,17-19,28H,10-11,13,15-16H2,1-5H3/b20-12+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute at Frederick Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from RasGRP3 (unknown origin) expressed in cells				J Med Chem 51: 5371-86 (2008) Article DOI: 10.1021/jm800380b BindingDB Entry DOI: 10.7270/Q21V5DSQ
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50244979 ((E)-(2-(hydroxymethyl)-5-oxo-4-(pyridin-2-ylmethyl...) Show SMILES CCCC(CCC)C(=O)OCC1(CO)C\C(=C/c2ccccn2)C(=O)O1 Show InChI InChI=1S/C20H27NO5/c1-3-7-15(8-4-2)18(23)25-14-20(13-22)12-16(19(24)26-20)11-17-9-5-6-10-21-17/h5-6,9-11,15,22H,3-4,7-8,12-14H2,1-2H3/b16-11+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.720	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute at Frederick Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from RasGRP3 (unknown origin) expressed in cells				J Med Chem 51: 5371-86 (2008) Article DOI: 10.1021/jm800380b BindingDB Entry DOI: 10.7270/Q21V5DSQ
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50244449 ((E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)...) Show SMILES CCCC(CCC)C(=O)OCC1(CO)C\C(=C/c2cn(C)c3ccccc23)C(=O)O1 Show InChI InChI=1S/C24H31NO5/c1-4-8-17(9-5-2)22(27)29-16-24(15-26)13-18(23(28)30-24)12-19-14-25(3)21-11-7-6-10-20(19)21/h6-7,10-12,14,17,26H,4-5,8-9,13,15-16H2,1-3H3/b18-12+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.840	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50280765 (CHEMBL4160647) Show SMILES Cn1cc(\C=C2/CC(CO)(COC(=O)C(C)(C)C)OC2=O)c2cc(Cl)ccc12 Show InChI InChI=1S/C21H24ClNO5/c1-20(2,3)19(26)27-12-21(11-24)9-13(18(25)28-21)7-14-10-23(4)17-6-5-15(22)8-16(14)17/h5-8,10,24H,9,11-12H2,1-4H3/b13-7+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50280768 (CHEMBL4163130) Show SMILES COc1ccc(\C=C2/CC(CO)(COC(=O)C(C)(C)C)OC2=O)cc1 Show InChI InChI=1S/C19H24O6/c1-18(2,3)17(22)24-12-19(11-20)10-14(16(21)25-19)9-13-5-7-15(23-4)8-6-13/h5-9,20H,10-12H2,1-4H3/b14-9+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50017892 (CHEMBL3289014) Show SMILES CCCC(CCC)C(=O)OCC1(CO)C\C(=C/c2cccc3ccn(C)c23)C(=O)O1 Show InChI InChI=1S/C24H31NO5/c1-4-7-18(8-5-2)22(27)29-16-24(15-26)14-20(23(28)30-24)13-19-10-6-9-17-11-12-25(3)21(17)19/h6,9-13,18,26H,4-5,7-8,14-16H2,1-3H3/b20-13+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Industrial Technology Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from recombinant human GFP-tagged RasGRP3 expressed in Escherichia coli BL21 after 5 mins by scintillation counting analysis...				Bioorg Med Chem 22: 3123-40 (2014) Article DOI: 10.1016/j.bmc.2014.04.024 BindingDB Entry DOI: 10.7270/Q2P270QK
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50280759 (CHEMBL4162516) Show SMILES CN(C)c1ccc(\C=C2/CC(CO)(COC(=O)C(C)(C)C)OC2=O)cc1 Show InChI InChI=1S/C20H27NO5/c1-19(2,3)18(24)25-13-20(12-22)11-15(17(23)26-20)10-14-6-8-16(9-7-14)21(4)5/h6-10,22H,11-13H2,1-5H3/b15-10+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	1.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50017891 (CHEMBL3289013) Show SMILES CCCC(CCC)C(=O)OCC1(CO)C\C(=C/c2ccc3ccn(C)c3c2)C(=O)O1 Show InChI InChI=1S/C24H31NO5/c1-4-6-19(7-5-2)22(27)29-16-24(15-26)14-20(23(28)30-24)12-17-8-9-18-10-11-25(3)21(18)13-17/h8-13,19,26H,4-7,14-16H2,1-3H3/b20-12+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Industrial Technology Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from recombinant human GFP-tagged RasGRP3 expressed in Escherichia coli BL21 after 5 mins by scintillation counting analysis...				Bioorg Med Chem 22: 3123-40 (2014) Article DOI: 10.1016/j.bmc.2014.04.024 BindingDB Entry DOI: 10.7270/Q2P270QK
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50280751 (CHEMBL4174397) Show SMILES COc1ccc(\C=C2/CC(CO)(COC(=O)c3ccc(Cl)cc3)OC2=O)cc1 Show InChI InChI=1S/C21H19ClO6/c1-26-18-8-2-14(3-9-18)10-16-11-21(12-23,28-20(16)25)13-27-19(24)15-4-6-17(22)7-5-15/h2-10,23H,11-13H2,1H3/b16-10+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50017889 (CHEMBL3289011) Show SMILES CCCC(CCC)C(=O)OCC1(CO)C\C(=C/c2cccc3n(C)ccc23)C(=O)O1 Show InChI InChI=1S/C24H31NO5/c1-4-7-17(8-5-2)22(27)29-16-24(15-26)14-19(23(28)30-24)13-18-9-6-10-21-20(18)11-12-25(21)3/h6,9-13,17,26H,4-5,7-8,14-16H2,1-3H3/b19-13+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Industrial Technology Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from recombinant human GFP-tagged RasGRP3 expressed in Escherichia coli BL21 after 5 mins by scintillation counting analysis...				Bioorg Med Chem 22: 3123-40 (2014) Article DOI: 10.1016/j.bmc.2014.04.024 BindingDB Entry DOI: 10.7270/Q2P270QK
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50244981 ((E)-(2-(hydroxymethyl)-5-oxo-4-(pyridin-3-ylmethyl...) Show SMILES CCCC(CCC)C(=O)OCC1(CO)C\C(=C/c2cccnc2)C(=O)O1 Show InChI InChI=1S/C20H27NO5/c1-3-6-16(7-4-2)18(23)25-14-20(13-22)11-17(19(24)26-20)10-15-8-5-9-21-12-15/h5,8-10,12,16,22H,3-4,6-7,11,13-14H2,1-2H3/b17-10+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute at Frederick Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from RasGRP3 (unknown origin) expressed in cells				J Med Chem 51: 5371-86 (2008) Article DOI: 10.1021/jm800380b BindingDB Entry DOI: 10.7270/Q21V5DSQ
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50245020 ((E)-(2-(hydroxymethyl)-5-oxo-4-(quinolin-2-ylmethy...) Show SMILES CCCC(CCC)C(=O)OCC1(CO)C\C(=C/c2ccc3ccccc3n2)C(=O)O1 Show InChI InChI=1S/C24H29NO5/c1-3-7-18(8-4-2)22(27)29-16-24(15-26)14-19(23(28)30-24)13-20-12-11-17-9-5-6-10-21(17)25-20/h5-6,9-13,18,26H,3-4,7-8,14-16H2,1-2H3/b19-13+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute at Frederick Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from RasGRP3 (unknown origin) expressed in cells				J Med Chem 51: 5371-86 (2008) Article DOI: 10.1021/jm800380b BindingDB Entry DOI: 10.7270/Q21V5DSQ
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50280773 (CHEMBL4174723) Show SMILES CC(C)(C)C(=O)OCC1(CO)C\C(=C/c2csc3ccccc23)C(=O)O1 Show InChI InChI=1S/C20H22O5S/c1-19(2,3)18(23)24-12-20(11-21)9-13(17(22)25-20)8-14-10-26-16-7-5-4-6-15(14)16/h4-8,10,21H,9,11-12H2,1-3H3/b13-8+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50244866 (CHEMBL511820 | rac-(E)-{2-(Hydroxymethyl)-4-[(4-ni...) Show SMILES CN(C)c1ccccc1C(=O)OCC1(CO)C\C(=C/c2ccc(cc2)[N+]([O-])=O)C(=O)O1 Show InChI InChI=1S/C22H22N2O7/c1-23(2)19-6-4-3-5-18(19)21(27)30-14-22(13-25)12-16(20(26)31-22)11-15-7-9-17(10-8-15)24(28)29/h3-11,25H,12-14H2,1-2H3/b16-11+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute at Frederick Curated by ChEMBL					Assay Description Binding affinity to RasGRP3 (unknown origin)				J Med Chem 51: 5198-220 (2008) Article DOI: 10.1021/jm8001907 BindingDB Entry DOI: 10.7270/Q2G44Q4B
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50280756 (CHEMBL4167589) Show SMILES CN(C)c1ccc(\C=C2/CC(CO)(COC(=O)c3ccc(Cl)cc3)OC2=O)cc1 Show InChI InChI=1S/C22H22ClNO5/c1-24(2)19-9-3-15(4-10-19)11-17-12-22(13-25,29-21(17)27)14-28-20(26)16-5-7-18(23)8-6-16/h3-11,25H,12-14H2,1-2H3/b17-11+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	1.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50280749 (CHEMBL4169454) Show SMILES Cn1cc(\C=C2/CC(CO)(COC(=O)C(C)(C)C)OC2=O)c2ccccc12 Show InChI InChI=1S/C21H25NO5/c1-20(2,3)19(25)26-13-21(12-23)10-14(18(24)27-21)9-15-11-22(4)17-8-6-5-7-16(15)17/h5-9,11,23H,10,12-13H2,1-4H3/b14-9+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	1.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50280771 (CHEMBL4160540) Show SMILES CCCCn1cc(\C=C2/CC(CO)(COC(=O)C(C)(C)C)OC2=O)c2ccccc12 Show InChI InChI=1S/C24H31NO5/c1-5-6-11-25-14-18(19-9-7-8-10-20(19)25)12-17-13-24(15-26,30-21(17)27)16-29-22(28)23(2,3)4/h7-10,12,14,26H,5-6,11,13,15-16H2,1-4H3/b17-12+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50280752 (CHEMBL4161221) Show SMILES Cn1cc(\C=C2/CC(CO)(COC(=O)C3CCC(CC3)C(C)(C)C)OC2=O)c2ccccc12 |(33.76,-11.61,;33.34,-10.13,;34.29,-8.91,;33.42,-7.64,;34.21,-6.31,;33.45,-4.98,;31.91,-4.98,;31.43,-3.51,;30.09,-4.27,;30.08,-5.81,;30.1,-2.73,;28.76,-3.49,;27.43,-2.71,;27.44,-1.17,;26.09,-3.48,;24.75,-2.69,;23.41,-3.45,;23.4,-5,;24.73,-5.78,;26.08,-5.02,;22.06,-5.75,;20.74,-4.98,;22.05,-7.29,;20.73,-6.51,;32.68,-2.6,;33.93,-3.51,;35.39,-3.04,;31.95,-8.07,;30.66,-7.25,;29.3,-7.97,;29.25,-9.51,;30.54,-10.31,;31.89,-9.6,)| Show InChI InChI=1S/C27H35NO5/c1-26(2,3)21-11-9-18(10-12-21)24(30)32-17-27(16-29)14-19(25(31)33-27)13-20-15-28(4)23-8-6-5-7-22(20)23/h5-8,13,15,18,21,29H,9-12,14,16-17H2,1-4H3/b19-13+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50245091 (CHEMBL519398 | rac-(E)-{2-(Hydroxymethyl)-4-[(4-ni...) Show SMILES OCC1(COC(=O)c2ccc(cc2)[N+]([O-])=O)C\C(=C/c2ccc(cc2)[N+]([O-])=O)C(=O)O1 Show InChI InChI=1S/C20H16N2O9/c23-11-20(12-30-18(24)14-3-7-17(8-4-14)22(28)29)10-15(19(25)31-20)9-13-1-5-16(6-2-13)21(26)27/h1-9,23H,10-12H2/b15-9+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute at Frederick Curated by ChEMBL					Assay Description Binding affinity to RasGRP3 (unknown origin)				J Med Chem 51: 5198-220 (2008) Article DOI: 10.1021/jm8001907 BindingDB Entry DOI: 10.7270/Q2G44Q4B
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50280757 (CHEMBL4175934) Show SMILES COc1ccc(cc1)C(=O)OCC1(CO)C\C(=C/c2ccc(Cl)cc2)C(=O)O1 Show InChI InChI=1S/C21H19ClO6/c1-26-18-8-4-15(5-9-18)19(24)27-13-21(12-23)11-16(20(25)28-21)10-14-2-6-17(22)7-3-14/h2-10,23H,11-13H2,1H3/b16-10+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50244865 (CHEMBL471153 | rac-(E)-{2-(Hydroxymethyl)-4-[(4-ni...) Show SMILES CN(C)c1cccc(c1)C(=O)OCC1(CO)C\C(=C/c2ccc(cc2)[N+]([O-])=O)C(=O)O1 Show InChI InChI=1S/C22H22N2O7/c1-23(2)19-5-3-4-16(11-19)20(26)30-14-22(13-25)12-17(21(27)31-22)10-15-6-8-18(9-7-15)24(28)29/h3-11,25H,12-14H2,1-2H3/b17-10+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute at Frederick Curated by ChEMBL					Assay Description Binding affinity to RasGRP3 (unknown origin)				J Med Chem 51: 5198-220 (2008) Article DOI: 10.1021/jm8001907 BindingDB Entry DOI: 10.7270/Q2G44Q4B
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50280754 (CHEMBL4175128) Show SMILES CN(C)c1ccc(cc1)C(=O)OCC1(CO)C\C(=C/c2ccc(Cl)cc2)C(=O)O1 Show InChI InChI=1S/C22H22ClNO5/c1-24(2)19-9-5-16(6-10-19)20(26)28-14-22(13-25)12-17(21(27)29-22)11-15-3-7-18(23)8-4-15/h3-11,25H,12-14H2,1-2H3/b17-11+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50280758 (CHEMBL4172461) Show SMILES OCC1(COC(=O)c2ccc(Cl)cc2)C\C(=C/c2ccc(Cl)cc2)C(=O)O1 Show InChI InChI=1S/C20H16Cl2O5/c21-16-5-1-13(2-6-16)9-15-10-20(11-23,27-19(15)25)12-26-18(24)14-3-7-17(22)8-4-14/h1-9,23H,10-12H2/b15-9+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50280772 (CHEMBL4165117) Show SMILES CC(C)(C)C(=O)OCC1(CO)C\C(=C/c2coc3ccccc23)C(=O)O1 Show InChI InChI=1S/C20H22O6/c1-19(2,3)18(23)25-12-20(11-21)9-13(17(22)26-20)8-14-10-24-16-7-5-4-6-15(14)16/h4-8,10,21H,9,11-12H2,1-3H3/b13-8+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50280745 (CHEMBL4163809) Show SMILES Cn1cc(\C=C2/CC(CO)(COC(=O)C3CCCCC3)OC2=O)c2ccccc12 Show InChI InChI=1S/C23H27NO5/c1-24-13-18(19-9-5-6-10-20(19)24)11-17-12-23(14-25,29-22(17)27)15-28-21(26)16-7-3-2-4-8-16/h5-6,9-11,13,16,25H,2-4,7-8,12,14-15H2,1H3/b17-11+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50280753 (CHEMBL4167900) Show SMILES CC(C)Cn1cc(\C=C2/CC(CO)(COC(=O)C(C)(C)C)OC2=O)c2ccccc12 Show InChI InChI=1S/C24H31NO5/c1-16(2)12-25-13-18(19-8-6-7-9-20(19)25)10-17-11-24(14-26,30-21(17)27)15-29-22(28)23(3,4)5/h6-10,13,16,26H,11-12,14-15H2,1-5H3/b17-10+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50244481 ((E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)...) Show SMILES COc1ccc(cc1)C(=O)OCC1(CO)C\C(=C/c2cn(C)c3ccccc23)C(=O)O1 Show InChI InChI=1S/C24H23NO6/c1-25-13-18(20-5-3-4-6-21(20)25)11-17-12-24(14-26,31-23(17)28)15-30-22(27)16-7-9-19(29-2)10-8-16/h3-11,13,26H,12,14-15H2,1-2H3/b17-11+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute at Frederick Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from RasGRP3 (unknown origin) expressed in cells				J Med Chem 51: 5371-86 (2008) Article DOI: 10.1021/jm800380b BindingDB Entry DOI: 10.7270/Q21V5DSQ
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50280763 (CHEMBL4175761) Show SMILES CC(C)(C)C(=O)OCC1(CO)C\C(=C/c2cn(CC3CC3)c3ccccc23)C(=O)O1 Show InChI InChI=1S/C24H29NO5/c1-23(2,3)22(28)29-15-24(14-26)11-17(21(27)30-24)10-18-13-25(12-16-8-9-16)20-7-5-4-6-19(18)20/h4-7,10,13,16,26H,8-9,11-12,14-15H2,1-3H3/b17-10+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	3.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50244974 ((E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)...) Show SMILES CN(C)c1ccc(cc1)C(=O)OCC1(CO)C\C(=C/c2cn(C)c3ccccc23)C(=O)O1 Show InChI InChI=1S/C25H26N2O5/c1-26(2)20-10-8-17(9-11-20)23(29)31-16-25(15-28)13-18(24(30)32-25)12-19-14-27(3)22-7-5-4-6-21(19)22/h4-12,14,28H,13,15-16H2,1-3H3/b18-12+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute at Frederick Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from RasGRP3 (unknown origin) expressed in cells				J Med Chem 51: 5371-86 (2008) Article DOI: 10.1021/jm800380b BindingDB Entry DOI: 10.7270/Q21V5DSQ
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50244482 ((4-(4-nitrobenzylidene)-2-(hydroxymethyl)-5-oxo-te...) Show SMILES CN(C)c1ccc(cc1)C(=O)OCC1(CO)C\C(=C/c2ccc(cc2)[N+]([O-])=O)C(=O)O1 Show InChI InChI=1S/C22H22N2O7/c1-23(2)18-9-5-16(6-10-18)20(26)30-14-22(13-25)12-17(21(27)31-22)11-15-3-7-19(8-4-15)24(28)29/h3-11,25H,12-14H2,1-2H3/b17-11+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute at Frederick Curated by ChEMBL					Assay Description Binding affinity to RasGRP3 (unknown origin)				J Med Chem 51: 5198-220 (2008) Article DOI: 10.1021/jm8001907 BindingDB Entry DOI: 10.7270/Q2G44Q4B
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50244482 ((4-(4-nitrobenzylidene)-2-(hydroxymethyl)-5-oxo-te...) Show SMILES CN(C)c1ccc(cc1)C(=O)OCC1(CO)C\C(=C/c2ccc(cc2)[N+]([O-])=O)C(=O)O1 Show InChI InChI=1S/C22H22N2O7/c1-23(2)18-9-5-16(6-10-18)20(26)30-14-22(13-25)12-17(21(27)31-22)11-15-3-7-19(8-4-15)24(28)29/h3-11,25H,12-14H2,1-2H3/b17-11+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute at Frederick Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from RasGRP3 (unknown origin) expressed in cells				J Med Chem 51: 5371-86 (2008) Article DOI: 10.1021/jm800380b BindingDB Entry DOI: 10.7270/Q21V5DSQ
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50244915 (CHEMBL472002 | rac-(E)-{2-(Hydroxymethyl)-4-[(3-ni...) Show SMILES CN(C)c1ccccc1C(=O)OCC1(CO)C\C(=C/c2cccc(c2)[N+]([O-])=O)C(=O)O1 Show InChI InChI=1S/C22H22N2O7/c1-23(2)19-9-4-3-8-18(19)21(27)30-14-22(13-25)12-16(20(26)31-22)10-15-6-5-7-17(11-15)24(28)29/h3-11,25H,12-14H2,1-2H3/b16-10+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute at Frederick Curated by ChEMBL					Assay Description Binding affinity to RasGRP3 (unknown origin)				J Med Chem 51: 5198-220 (2008) Article DOI: 10.1021/jm8001907 BindingDB Entry DOI: 10.7270/Q2G44Q4B
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50244856 (CHEMBL461754 | rac-(E)-{2-(Hydroxymethyl)-4-[(4-me...) Show SMILES COc1ccc(\C=C2/CC(CO)(COC(=O)c3ccc(OC)cc3)OC2=O)cc1 Show InChI InChI=1S/C22H22O7/c1-26-18-7-3-15(4-8-18)11-17-12-22(13-23,29-21(17)25)14-28-20(24)16-5-9-19(27-2)10-6-16/h3-11,23H,12-14H2,1-2H3/b17-11+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50280755 (CHEMBL4175333) Show SMILES CC(C)(C)C(=O)OCC1(CO)C\C(=C\c2csc3ccccc23)C(=O)O1 Show InChI InChI=1S/C20H22O5S/c1-19(2,3)18(23)24-12-20(11-21)9-13(17(22)25-20)8-14-10-26-16-7-5-4-6-15(14)16/h4-8,10,21H,9,11-12H2,1-3H3/b13-8-	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	4.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50280746 (CHEMBL4161062) Show SMILES Cn1cc(\C=C2\CC(CO)(COC(=O)C(C)(C)C)OC2=O)c2cc(Cl)ccc12 Show InChI InChI=1S/C21H24ClNO5/c1-20(2,3)19(26)27-12-21(11-24)9-13(18(25)28-21)7-14-10-23(4)17-6-5-15(22)8-16(14)17/h5-8,10,24H,9,11-12H2,1-4H3/b13-7-	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	4.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50245021 ((Z)-(2-(hydroxymethyl)-5-oxo-4-(quinolin-2-ylmethy...) Show SMILES CCCC(CCC)C(=O)OCC1(CO)C\C(=C\c2ccc3ccccc3n2)C(=O)O1 Show InChI InChI=1S/C24H29NO5/c1-3-7-18(8-4-2)22(27)29-16-24(15-26)14-19(23(28)30-24)13-20-12-11-17-9-5-6-10-21(17)25-20/h5-6,9-13,18,26H,3-4,7-8,14-16H2,1-2H3/b19-13-	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute at Frederick Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from RasGRP3 (unknown origin) expressed in cells				J Med Chem 51: 5371-86 (2008) Article DOI: 10.1021/jm800380b BindingDB Entry DOI: 10.7270/Q21V5DSQ
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50244643 (CHEMBL452307 | rac-(E)-(4-{[4-(Dimethylamino)pheny...) Show SMILES CN(C)c1ccc(\C=C2/CC(CO)(COC(=O)c3ccc(cc3)N(C)C)OC2=O)cc1 Show InChI InChI=1S/C24H28N2O5/c1-25(2)20-9-5-17(6-10-20)13-19-14-24(15-27,31-23(19)29)16-30-22(28)18-7-11-21(12-8-18)26(3)4/h5-13,27H,14-16H2,1-4H3/b19-13+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.68	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute at Frederick Curated by ChEMBL					Assay Description Binding affinity to RasGRP3 (unknown origin)				J Med Chem 51: 5198-220 (2008) Article DOI: 10.1021/jm8001907 BindingDB Entry DOI: 10.7270/Q2G44Q4B
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50280764 (CHEMBL4171253) Show SMILES COc1ccc2n(C)cc(\C=C3/CC(CO)(COC(=O)C(C)(C)C)OC3=O)c2c1 Show InChI InChI=1S/C22H27NO6/c1-21(2,3)20(26)28-13-22(12-24)10-14(19(25)29-22)8-15-11-23(4)18-7-6-16(27-5)9-17(15)18/h6-9,11,24H,10,12-13H2,1-5H3/b14-8+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	4.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50244451 ((E)-(2-(hydroxymethyl)-4-((1-methyl-1H-indol-3-yl)...) Show SMILES CC(C)CC(CC(C)C)C(=O)OCC1(CO)C\C(=C/c2cn(C)c3ccccc23)C(=O)O1 Show InChI InChI=1S/C26H35NO5/c1-17(2)10-19(11-18(3)4)24(29)31-16-26(15-28)13-20(25(30)32-26)12-21-14-27(5)23-9-7-6-8-22(21)23/h6-9,12,14,17-19,28H,10-11,13,15-16H2,1-5H3/b20-12+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50280769 (CHEMBL4167264) Show SMILES CCCCCCC(=O)OCC1(CO)C\C(=C/c2cn(C)c3ccccc23)C(=O)O1 Show InChI InChI=1S/C23H29NO5/c1-3-4-5-6-11-21(26)28-16-23(15-25)13-17(22(27)29-23)12-18-14-24(2)20-10-8-7-9-19(18)20/h7-10,12,14,25H,3-6,11,13,15-16H2,1-2H3/b17-12+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	5.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50244914 (CHEMBL472001 | rac-(E)-{2-(Hydroxymethyl)-4-[(3-ni...) Show SMILES CN(C)c1cccc(c1)C(=O)OCC1(CO)C\C(=C/c2cccc(c2)[N+]([O-])=O)C(=O)O1 Show InChI InChI=1S/C22H22N2O7/c1-23(2)18-7-4-6-16(11-18)20(26)30-14-22(13-25)12-17(21(27)31-22)9-15-5-3-8-19(10-15)24(28)29/h3-11,25H,12-14H2,1-2H3/b17-9+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute at Frederick Curated by ChEMBL					Assay Description Binding affinity to RasGRP3 (unknown origin)				J Med Chem 51: 5198-220 (2008) Article DOI: 10.1021/jm8001907 BindingDB Entry DOI: 10.7270/Q2G44Q4B
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50244452 ((4-(4-nitrobenzylidene)-2-(hydroxymethyl)-5-oxo-te...) Show SMILES COc1ccc(cc1)C(=O)OCC1(CO)C\C(=C/c2ccc(cc2)[N+]([O-])=O)C(=O)O1 Show InChI InChI=1S/C21H19NO8/c1-28-18-8-4-15(5-9-18)19(24)29-13-21(12-23)11-16(20(25)30-21)10-14-2-6-17(7-3-14)22(26)27/h2-10,23H,11-13H2,1H3/b16-10+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Cancer Institute at Frederick Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from RasGRP3 (unknown origin) expressed in cells				J Med Chem 51: 5371-86 (2008) Article DOI: 10.1021/jm800380b BindingDB Entry DOI: 10.7270/Q21V5DSQ
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50244798 (CHEMBL461374 | rac-(E)-{2-(Hydroxymethyl)-4-[(4-me...) Show SMILES COc1ccc(\C=C2/CC(CO)(COC(=O)c3ccc(cc3)N(C)C)OC2=O)cc1 Show InChI InChI=1S/C23H25NO6/c1-24(2)19-8-6-17(7-9-19)21(26)29-15-23(14-25)13-18(22(27)30-23)12-16-4-10-20(28-3)11-5-16/h4-12,25H,13-15H2,1-3H3/b18-12+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair
Ras guanyl-releasing protein 3 (Homo sapiens (Human))	BDBM50280767 (CHEMBL4167457) Show SMILES Cn1nc(\C=C2/CC(CO)(COC(=O)C(C)(C)C)OC2=O)c2ccccc12 Show InChI InChI=1S/C20H24N2O5/c1-19(2,3)18(25)26-12-20(11-23)10-13(17(24)27-20)9-15-14-7-5-6-8-16(14)22(4)21-15/h5-9,23H,10-12H2,1-4H3/b13-9+	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	7.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Seoul National University Curated by ChEMBL					Assay Description Displacement of [3H]PDBu from full length MBP-tagged human RasGRP3 expressed in Escherichia coli BL21 (DE3) after 5 mins by scintillation counting				J Med Chem 61: 6261-6276 (2018) Article DOI: 10.1021/acs.jmedchem.8b00661 BindingDB Entry DOI: 10.7270/Q28P632D
					More data for this Ligand-Target Pair

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